American Airlines flight AA 4381: Multiple routes

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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
Daily 06:59 New York LaGuardia (LGA) B 08:55 Saint Louis (STL) 1
AA 4381 Non-stop Embraer EMB 175 (E75) 2:56 Effective 2025-10-06 through 2025-11-01
Mon 07:31 Saint Louis (STL) 1 10:59 New York LaGuardia (LGA) B
AA 4381 Non-stop Embraer EMB 175 (E75) 2:28 Operates only on 2025-05-05
Mon-Fri 07:32 Saint Louis (STL) 1 11:00 New York LaGuardia (LGA) B
AA 4381 Non-stop Embraer EMB 175 (E75) 2:28 Effective 2025-05-06 through 2025-06-04
Sat 07:32 Saint Louis (STL) 1 11:00 New York LaGuardia (LGA) B
AA 4381 Non-stop Embraer EMB 170 / EMB 175 (E70) 2:28 Effective 2025-05-10 through 2025-05-31
Mon-Fri,Sun 10:02 Saint Louis (STL) 1 13:30 New York LaGuardia (LGA) B
AA 4381 Non-stop Embraer EMB 175 (E75) 2:28 Effective 2025-07-06 through 2025-08-05
Daily 10:25 Saint Louis (STL) 1 13:54 New York LaGuardia (LGA) B
AA 4381 Non-stop Embraer EMB 175 (E75) 2:29 Effective 2025-08-06 through 2025-09-02
Daily 10:26 John Glenn Columbus (CMH) 12:10 New York LaGuardia (LGA) B
AA 4381 Non-stop Embraer EMB 175 (E75) 1:44 Effective 2026-01-06 through 2026-02-11
Daily 10:28 John Glenn Columbus (CMH) 12:12 New York LaGuardia (LGA) B
AA 4381 Non-stop Embraer EMB 175 (E75) 1:44 Effective from 2026-02-12
Daily 10:33 John Glenn Columbus (CMH) 12:15 New York LaGuardia (LGA) B
AA 4381 Non-stop Embraer EMB 175 (E75) 1:42 Effective 2025-12-03 through 2025-12-17
Daily 10:34 John Glenn Columbus (CMH) 12:17 New York LaGuardia (LGA) B
AA 4381 Non-stop Embraer EMB 175 (E75) 1:43 Effective 2025-12-18 through 2026-01-05
Mon-Fri,Sun 10:35 Saint Louis (STL) 1 13:59 New York LaGuardia (LGA) B
AA 4381 Non-stop Embraer EMB 175 (E75) 2:24 Effective 2025-06-05 through 2025-07-04
Daily 10:35 John Glenn Columbus (CMH) 12:15 New York LaGuardia (LGA) B
AA 4381 Non-stop Embraer EMB 175 (E75) 1:40 Effective 2025-11-02 through 2025-12-02
Daily 15:09 Traverse City (TVC) 15:33 Chicago O'Hare (ORD) 3
AA 4381 Non-stop Embraer EMB 175 (E75) 1:24 Effective 2025-09-03 through 2025-10-05
Sat 16:39 Oklahoma City (OKC) 20:46 Miami (MIA)
AA 4381 Non-stop Embraer EMB 175 (E75) 3:07 Effective 2025-06-07 through 2025-06-28
Sat 16:43 Oklahoma City (OKC) 20:54 Miami (MIA)
AA 4381 Non-stop Embraer EMB 175 (E75) 3:11 Effective 2025-07-05 through 2025-08-02
Daily 18:00 Philadelphia (PHL) 19:25 Boston Logan (BOS) B
AA 4381 Non-stop Embraer EMB 175 (E75) 1:25 Valid until 2025-05-04
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This flight number is listed as serving the following routes:


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American Airlines flight AA 4381: Multiple routes
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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
American Airlines AA4381
06:59
New York LaGuardia (LGA) B

08:55
Saint Louis (STL) 1
Effective 2025-10-06 through 2025-11-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:56, non-stop
Embraer EMB 175 (E75)
American Airlines AA4381
07:31
Saint Louis (STL) 1

10:59
New York LaGuardia (LGA) B
Operates only on 2025-05-05
Mon
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
-
Duration: 2:28, non-stop
Embraer EMB 175 (E75)
American Airlines AA4381
07:32
Saint Louis (STL) 1

11:00
New York LaGuardia (LGA) B
Effective 2025-05-06 through 2025-06-04
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
-
Duration: 2:28, non-stop
Embraer EMB 175 (E75)
American Airlines AA4381
07:32
Saint Louis (STL) 1

11:00
New York LaGuardia (LGA) B
Effective 2025-05-10 through 2025-05-31
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 2:28, non-stop
Embraer EMB 170 / EMB 175 (E70)
American Airlines AA4381
10:02
Saint Louis (STL) 1

13:30
New York LaGuardia (LGA) B
Effective 2025-07-06 through 2025-08-05
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 2:28, non-stop
Embraer EMB 175 (E75)
American Airlines AA4381
10:25
Saint Louis (STL) 1

13:54
New York LaGuardia (LGA) B
Effective 2025-08-06 through 2025-09-02
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:29, non-stop
Embraer EMB 175 (E75)
American Airlines AA4381
10:26
John Glenn Columbus (CMH)

12:10
New York LaGuardia (LGA) B
Effective 2026-01-06 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:44, non-stop
Embraer EMB 175 (E75)
American Airlines AA4381
10:28
John Glenn Columbus (CMH)

12:12
New York LaGuardia (LGA) B
Effective from 2026-02-12
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:44, non-stop
Embraer EMB 175 (E75)
American Airlines AA4381
10:33
John Glenn Columbus (CMH)

12:15
New York LaGuardia (LGA) B
Effective 2025-12-03 through 2025-12-17
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:42, non-stop
Embraer EMB 175 (E75)
American Airlines AA4381
10:34
John Glenn Columbus (CMH)

12:17
New York LaGuardia (LGA) B
Effective 2025-12-18 through 2026-01-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:43, non-stop
Embraer EMB 175 (E75)
American Airlines AA4381
10:35
Saint Louis (STL) 1

13:59
New York LaGuardia (LGA) B
Effective 2025-06-05 through 2025-07-04
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 2:24, non-stop
Embraer EMB 175 (E75)
American Airlines AA4381
10:35
John Glenn Columbus (CMH)

12:15
New York LaGuardia (LGA) B
Effective 2025-11-02 through 2025-12-02
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:40, non-stop
Embraer EMB 175 (E75)
American Airlines AA4381
15:09
Traverse City (TVC)

15:33
Chicago O'Hare (ORD) 3
Effective 2025-09-03 through 2025-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:24, non-stop
Embraer EMB 175 (E75)
American Airlines AA4381
16:39
Oklahoma City (OKC)

20:46
Miami (MIA)
Effective 2025-06-07 through 2025-06-28
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 3:07, non-stop
Embraer EMB 175 (E75)
American Airlines AA4381
16:43
Oklahoma City (OKC)

20:54
Miami (MIA)
Effective 2025-07-05 through 2025-08-02
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 3:11, non-stop
Embraer EMB 175 (E75)
American Airlines AA4381
18:00
Philadelphia (PHL)

19:25
Boston Logan (BOS) B
Valid until 2025-05-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:25, non-stop
Embraer EMB 175 (E75)
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This flight number is listed as serving the following routes:
  • John Glenn Columbus (CMH) - New York LaGuardia (LGA)
  • New York LaGuardia (LGA) - Saint Louis (STL)
  • Oklahoma City (OKC) - Miami (MIA)
  • Philadelphia (PHL) - Boston Logan (BOS)
  • Traverse City (TVC) - Chicago O'Hare (ORD)
All American Airlines flights
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